[Comparison of serum CA-125 level in ruptured and unruptured tubal pregnancies in Yazd/Iran during 2001-2006]

This study aimed to determine if serial measurement of serum CA-125 level could be used as a useful test in the differential diagnosis of intact and ruptured tubal pregnancies. In a single-blind prospective controlled clinical study, 59 women with tubal pregnancy of 6-12 weeks [26 women with ruptured tubal pregnancy, 33 women with intact tubal pregnancy and 59 women with normal intrauterine pregnancy of the same gestational age as control group] were studied prospectively. Serum CA-125 levels were measured in all women and compared among three groups. Demographic features [age, gestational age, parity and educational level] were not significantly different in three groups. CA-125 level in ruptured tubal pregnancy group was significantly higher than that in control group [P = 0.04]. Both these two groups had higher levels of CA-125 comparing to the intact tubal pregnancy group [P = 0.001, P = 0.006, respectively]. In intact tubal pregnancies managed with medical treatment, serial measurements of CA-125 could be a supplementary test for an early diagnosis of tubal rupture

[Comparison of closure of subcutaneous tissue versus non-closure in relation to wound infection and disruption after cesarean section delivery in obese patients]

Wound disruption after cesarean section is a common complication; and obesity has been identified as strong independent risk factor for wound complications. The aim of this study was to test the hypothesis that closure of the subcutaneous fat decreases the incidence of wound infection and disruption after cesarean delivery. In a clinical trial study conducted in Yazd, a hundred women with at least 2 cm of subcutaneous fat and cesarean delivery were included in the study. In 50 patients, subcutaneous tissue was closed using synthetic suture [group A], while in 50 control patients subcutaneous tissue was not closed [group B]. Two groups were compare in relation to wound infection and disruption. Data were analyzed using student and X[2] tests. Complications leading to wound infections [positive culture] were 2 women in group A and 5 women in group B [P<0.05] and disruption or opening of the incision were in 7 women in group A and in 17 women in group B [P<0.01]. Closure of the subcutaneous tissue can significantly reduce the rate of postoperative wound disruption in women with at least 2 cm of subcutaneous adipose tissue